Search results for "Cigarette smoke exposure"

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Airway epithelial dysfunction and mesenchymal transition in chronic obstructive pulmonary disease: Role of Oct-4

2021

Abstract The airway epithelium is a dynamic tissue that undergoes slow but constant renewal. Dysregulation of airway epithelial function related to cigarette smoke exposure plays an important role in the pathophysiology of COPD. Oct4 is a transcription factor responsible for maintaining cellular self-renewal and regeneration, and CD146 and CD105/Endoglin are adhesion molecules involved in cell proliferation, differentiation, epithelial-mesenchymal-transition and tissue remodeling. Bronchial biopsy specimens (BBs) were obtained from 7 healthy controls (HC) and 10 COPD and subjected to paraffin embedding; BBs from HC were also used for epithelial cell expansion and pHBEC/ALI (air-liquid inter…

AdultMalePathologymedicine.medical_specialtyEMT (epithelial-mesenchymal transition)Epithelial-Mesenchymal TransitionRespiratory SystemOct-4CD146 AntigenGeneral Biochemistry Genetics and Molecular BiologyCigarette SmokingPulmonary Disease Chronic ObstructiveAirway epithelium de-differentiationHumansMedicineGeneral Pharmacology Toxicology and PharmaceuticsAgedCOPDbusiness.industryCell adhesion moleculeMesenchymal stem cellEndoglinCell DifferentiationGeneral MedicineMiddle AgedEndoglinmedicine.diseaseCigarette smoke exposureEpitheliumrespiratory tract diseasesCD105medicine.anatomical_structureCD146Case-Control StudiesImmunohistochemistryRespiratory epitheliumCD146FemalebusinessOctamer Transcription Factor-3Life Sciences
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